D-GLUCARATE FROM AOR.D-Glucarate is a phytochemical found in such fruits and vegetables as orange pith and broccoli. Formulated by AOR, D-Glucarate + Milk Thistle inhibits an enzyme known as beta-glucuronidase, which suppresses the body's ability to detoxify many toxins using the glucuronidation pathway. D-Glucarate + Milk Thistle contains dry milk thistle extract, which helps to support liver function and is used as a liver protectant. [VEGETABLE CAPSULE]
1 capsule contains:
Calcium D-Glucarate 150mg
Milk Thistle Dry Extract (80% silymarin) 175mg
Non-medicinal Ingredients:
microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.
Important Information:
Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct. Do not use if you are pregnant or breastfeeding, have a liver or eye condition, or have Sly disease. Consult a health care practitioner prior to use if you are taking other medications or antibiotics, for use beyond 28 days, or if symptoms persist or worsen. Discontinue use if hypersensitivity develops (such as an allergy) or if symptoms of liver trouble or corneal clouding develop.
Dosage
Take one capsule twice daily with food, or as directed by a qualified health care practitioner. Use for a minimum of three weeks to see beneficial effects.
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AOR Canada is the innovative formulators of Canada’s best-selling antioxidant support,
AOR Advanced B Complex
and
AOR Tri-B12. They are also known for their top bone health supplements, Ortho Adapt and Bone Basics. You can also
SHOP AOR's Nattokinase, and trusted Curcumin Ultra, Curcumin Active and Curcumin95 inflammation support at ca. AOR are leaders in natural health with innovative product development.
Glucuronidation: Phase II Detoxification
The body makes use of intricate detoxification pathways to process xenobiotic and naturally occurring toxins. One of the most important such pathways is glucuronidation, in which UGT
enzymes
(uridine 5'-diphospho-glucuronosyltransferase) neutralize carcinogens by binding them to a molecule of glucuronic acid. This is an essential part of phase II detoxification. Glucuronidation renders potential carcinogens less hazardous to the cells of the body. It also makes many such chemicals easier for the body to excrete through the urine or the bile. Glucuronidation generally glucuronidates chemical carcinogens, steroid hormones, and other lipid-soluble toxins to either neutralize or detoxify them. The vital neutralization of toxins by glucuronidation can be undone by an enzyme known as beta glucuronidase. This enzyme frees up the original carcinogen from its glucuronic acid "handcuffs." Beta-glucuronidase is present in the body's cells and is also produced by some fecal bacteria. The activity of beta-glucuronidase increases with age.
D-Glucarate
D-glucarate is a substance made in small amounts by the body but found mainly in foods like oranges and cruciferous vegetables like broccoli. Interestingly enough, such foods also contain other substances that promote detoxification and healthy cell growth, including glucoraphanin glucosinolate (SGS),
IP6, DIM and I3C. D-Glucarate reduces the activity of the killer beta-glucuronidase enzyme in tissues all over the body, including key organs like the liver, spleen, breast, lung, and prostate resulting in higher net glucuronidation activity. This boost to your body's glucuronidation capacity helps to ensure that those pollutants and toxins that have been neutralized by UGTs will stay neutralized, and be safely passed out through the urine or the bile.
D-Glucarate & Supports Healthy Immune Function
As you'd expect from a nutrient that is used up in the detoxification process, people exposed to a toxic environment have abnormal levels of D-Glucarate in their tissues and biological fluids. Some patients also have disrupted D-Glucarate levels. Impaired glucuronidation has been linked to susceptibility to many unhealthy cells and other diseases in humans and in other species. Human research reveals links between toxic environments, glucuronidation, and beta-glucuronidase; and also between glucuronidation, beta-glucuronidase activity, and other diseases.
Breast Health
Studies in animals have found that D-Glucarate supplements provide powerful, effective support for the body's natural defences. In one study, giving animals access to D-Glucarate supplements during exposure to the carcinogen DMBA but then had the supplement taken away, the brief intevention still managed to reduce the number of breast tumors the animals formed by 18% compared to animals who never received the supplement. More strikingly, if the scientists waited until the unwanted cells had already formed in the animals, and only then allowed them access to D-Glucarate, breast tumor formation was cut by 42%. And best of all, supplementation began from the first day of chemical exposure, and continued on throughout the study, D-Glucarate cut tumor formation neatly in half. The results of another study were even more impressive: after the animals were exposed to DMBA, those consuming D-Glucarate supplements developed 70% fewer breast tumors than those that did not.
Prostate Health
The failure of the glucuronidation machinery is also closely associated with prostate health. UGT activity is reduced in prostate unwanted cells when they are exposed to high levels of dihydrotestosterone (DHT), the form of
testosterone
most responsible for promoting unhealthy prostate health. Men with prostate issues are three times as likely as healthy men to have the gene for a weakened version of the UGT enzyme that glucuronidates DHT. D-Glucarate suppresses the killer betaglucuronidase enzyme in the prostate just as it does in other tissues. Scientists at the AMC Research center now report that D-Glucarate supplements causes a 30% inhibition of the growth of prostate tumours in animals with existing prostatic issues.
In addition to these gender-specific threats, scientists have also piled on evidence that D-Glucarate supplementation supports healthy cell growth "equal-opportunity" diseases, such as those of the colon, the lung, the skin, and the liver, and have found elevated beta-glucuronidase activity in the tumors of human victims of lung issues. Beyond supporting the body's detoxification systems, D-Glucarate supplements also appear to make the cells of the body themselves less prone to carcinogenic stimulation. This property is also shared by milk thistle!
Milk Thistle
Milk thistle has been used for thousands of years in traditional medicine to help treat various liver diseases. Early clinical studies examined its therapeutic effects in alcoholic cirrhosis of the liver,
hepatitis, and fibrosis. It is known for protecting the liver and helping the liver self-regenerate after damage, helping to maintain and improve the general functioning of the liver. The liver has many functions, one of which is detoxification. When the liver is functioning optimally, detoxification can occur more efficiently. When any part of the detoxification system is compromised, including liver function, toxins can build-up in the body, causing illness and disease.
Silymarin's Benefits for the Liver
More recent studies have isolated silymarin, milk thistle's main active ingredient, which is actually a group of flavonolignans called silybins. These studies are beginning to discover just how powerful silymarin can be. It acts as an antioxidant, protecting cells, especially liver cells, from free-radical damage. It also protects cell membranes from lipid peroxidation, making them more stable and functional thereby protecting the cells. It might even protect cells by occupying hepatocyte binding sites so that toxins can't penetrate into the cells. Silymarin stimulates DNA synthesis in hepatocytes, the liver cells, which promotes liver tissue repair and regeneration. Since the liver is where most detoxification happens, it's important to keep it functioning optimally.
More of Milk Thistle's Power Revealed
It also helps prevent inflammation in various tissues by inhibiting NF-kB and modulating other pro-inflammatory signals, making it potentially therapeutic in the many illnesses related to inflammation. Other studies have demonstrated metal-chelating effects of silymarin, including iron and arsenic. Healthy immune system has also been the topic of many silymarin or milk thistle studies lately. One study even found that milk thistle protected both the liver and the heart from chemotherapy damage. Another study found that silymarin actually inhibits tumour cell proliferation in kidney while protecting healthy cells!
Silymarin also appears to benefit metabolic parameters. The results of one study showed significant improvements in various cholesterol and blood sugar parameters such as LDL, triglycerides, fasting blood glucose, HbA1c and others in silymarin treated patients. Another
diabetes
study found that amyloid
protein
misfolding and aggregation may be a factor in creating dysfunctional islet cells in the
pancreas
where insulin is synthesized and excreted from! Amyloid aggregation is associated with Alzheimer's disease, and studies have already had success in reducing the amyloid-beta plaque count in animal models of Alzheimer's disease!
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Product Details
Glucuronidation: Phase II Detoxification
The body makes use of intricate detoxification pathways to process xenobiotic and naturally occurring toxins. One of the most important such pathways is glucuronidation, in which UGT
enzymes
(uridine 5'-diphospho-glucuronosyltransferase) neutralize carcinogens by binding them to a molecule of glucuronic acid. This is an essential part of phase II detoxification. Glucuronidation renders potential carcinogens less hazardous to the cells of the body. It also makes many such chemicals easier for the body to excrete through the urine or the bile. Glucuronidation generally glucuronidates chemical carcinogens, steroid hormones, and other lipid-soluble toxins to either neutralize or detoxify them. The vital neutralization of toxins by glucuronidation can be undone by an enzyme known as beta glucuronidase. This enzyme frees up the original carcinogen from its glucuronic acid "handcuffs." Beta-glucuronidase is present in the body's cells and is also produced by some fecal bacteria. The activity of beta-glucuronidase increases with age.
D-Glucarate
D-glucarate is a substance made in small amounts by the body but found mainly in foods like oranges and cruciferous vegetables like broccoli. Interestingly enough, such foods also contain other substances that promote detoxification and healthy cell growth, including glucoraphanin glucosinolate (SGS),
IP6, DIM and I3C. D-Glucarate reduces the activity of the killer beta-glucuronidase enzyme in tissues all over the body, including key organs like the liver, spleen, breast, lung, and prostate resulting in higher net glucuronidation activity. This boost to your body's glucuronidation capacity helps to ensure that those pollutants and toxins that have been neutralized by UGTs will stay neutralized, and be safely passed out through the urine or the bile.
D-Glucarate & Supports Healthy Immune Function
As you'd expect from a nutrient that is used up in the detoxification process, people exposed to a toxic environment have abnormal levels of D-Glucarate in their tissues and biological fluids. Some patients also have disrupted D-Glucarate levels. Impaired glucuronidation has been linked to susceptibility to many unhealthy cells and other diseases in humans and in other species. Human research reveals links between toxic environments, glucuronidation, and beta-glucuronidase; and also between glucuronidation, beta-glucuronidase activity, and other diseases.
Breast Health
Studies in animals have found that D-Glucarate supplements provide powerful, effective support for the body's natural defences. In one study, giving animals access to D-Glucarate supplements during exposure to the carcinogen DMBA but then had the supplement taken away, the brief intevention still managed to reduce the number of breast tumors the animals formed by 18% compared to animals who never received the supplement. More strikingly, if the scientists waited until the unwanted cells had already formed in the animals, and only then allowed them access to D-Glucarate, breast tumor formation was cut by 42%. And best of all, supplementation began from the first day of chemical exposure, and continued on throughout the study, D-Glucarate cut tumor formation neatly in half. The results of another study were even more impressive: after the animals were exposed to DMBA, those consuming D-Glucarate supplements developed 70% fewer breast tumors than those that did not.
Prostate Health
The failure of the glucuronidation machinery is also closely associated with prostate health. UGT activity is reduced in prostate unwanted cells when they are exposed to high levels of dihydrotestosterone (DHT), the form of
testosterone
most responsible for promoting unhealthy prostate health. Men with prostate issues are three times as likely as healthy men to have the gene for a weakened version of the UGT enzyme that glucuronidates DHT. D-Glucarate suppresses the killer betaglucuronidase enzyme in the prostate just as it does in other tissues. Scientists at the AMC Research center now report that D-Glucarate supplements causes a 30% inhibition of the growth of prostate tumours in animals with existing prostatic issues.
In addition to these gender-specific threats, scientists have also piled on evidence that D-Glucarate supplementation supports healthy cell growth "equal-opportunity" diseases, such as those of the colon, the lung, the skin, and the liver, and have found elevated beta-glucuronidase activity in the tumors of human victims of lung issues. Beyond supporting the body's detoxification systems, D-Glucarate supplements also appear to make the cells of the body themselves less prone to carcinogenic stimulation. This property is also shared by milk thistle!
Milk Thistle
Milk thistle has been used for thousands of years in traditional medicine to help treat various liver diseases. Early clinical studies examined its therapeutic effects in alcoholic cirrhosis of the liver,
hepatitis, and fibrosis. It is known for protecting the liver and helping the liver self-regenerate after damage, helping to maintain and improve the general functioning of the liver. The liver has many functions, one of which is detoxification. When the liver is functioning optimally, detoxification can occur more efficiently. When any part of the detoxification system is compromised, including liver function, toxins can build-up in the body, causing illness and disease.
Silymarin's Benefits for the Liver
More recent studies have isolated silymarin, milk thistle's main active ingredient, which is actually a group of flavonolignans called silybins. These studies are beginning to discover just how powerful silymarin can be. It acts as an antioxidant, protecting cells, especially liver cells, from free-radical damage. It also protects cell membranes from lipid peroxidation, making them more stable and functional thereby protecting the cells. It might even protect cells by occupying hepatocyte binding sites so that toxins can't penetrate into the cells. Silymarin stimulates DNA synthesis in hepatocytes, the liver cells, which promotes liver tissue repair and regeneration. Since the liver is where most detoxification happens, it's important to keep it functioning optimally.
More of Milk Thistle's Power Revealed
It also helps prevent inflammation in various tissues by inhibiting NF-kB and modulating other pro-inflammatory signals, making it potentially therapeutic in the many illnesses related to inflammation. Other studies have demonstrated metal-chelating effects of silymarin, including iron and arsenic. Healthy immune system has also been the topic of many silymarin or milk thistle studies lately. One study even found that milk thistle protected both the liver and the heart from chemotherapy damage. Another study found that silymarin actually inhibits tumour cell proliferation in kidney while protecting healthy cells!
Silymarin also appears to benefit metabolic parameters. The results of one study showed significant improvements in various cholesterol and blood sugar parameters such as LDL, triglycerides, fasting blood glucose, HbA1c and others in silymarin treated patients. Another
diabetes
study found that amyloid
protein
misfolding and aggregation may be a factor in creating dysfunctional islet cells in the
pancreas
where insulin is synthesized and excreted from! Amyloid aggregation is associated with Alzheimer's disease, and studies have already had success in reducing the amyloid-beta plaque count in animal models of Alzheimer's disease!
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