From Pure Encapsulations, this SAMe offers Enhanced-stability to support healthy mood balance and osteoarthritic joint comfort. SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also promotes healthy mood balance, as indicated in over 40 clinical studies. [CAPS]
Medicinal ingredients (per capsule):
SAMe (from S-Adenosyl-L-methionine disulfate tosylate) 200 mg
Non-medicinal Ingredients:
Vegetarian capsule (hypromellose, water), Hypoallergenic plant cellulose, Calcium oxide, Ascorbyl palmitate, Calcium chloride.
Important Information:
Do not use if you are pregnant, breastfeeding or have been diagnosed with bipolar disorder. Consult a healthcare practitioner prior to use if you are taking medication such as antidepressants, hepatoxic drugs or monoamine oxidase (MAO) inhibitors. Do not take at night, as the product may cause anxiety, restlessness and insomnia. Consult a healthcare practitioner if symptoms persist or worsen. Some people may experience mild gastrointestinal upsets, anxiety, restlessness, insomnia, hyperactive muscle movement, and hypomania, in which case discontinue use and consult a healthcare practitioner.
Dosage
Adults: For healthy mood balance, take 2 capsules 1-3 times daily. For osteoarthritic pain, take 2 capsules 3 times daily. Take in divided doses, between meals, or as directed by a healthcare practitioner. For osteoarthritic pain, use for a minimum of 8 weeks to see beneficial effects. Consult a healthcare practitioner for use beyond 12 weeks.
Quality Vitamins Trusted by Healthcare Professionals
Pure Encapsulations offers hypoallergenic natural health supplements that undergo third-party testing for purity and potency. Pure Encapsulations is a leading brand among healthcare practitioners and is free from gluten, GMO, fillers and preservatives. Top-selling vitamins and minerals include; Magnesium Glycinate and B-Complex Plus. With Pure Encapsulations you have quality assurance.
PURE ENCAPSULATIONS
SAMe (S-Adenosylmethionine)
Enhanced-stability SAMe to support healthy mood balance and osteoarthritic joint comfort
Provides 200 mg per capsule of enhanced-stability form SAMe
Manufactured using a solvent-free manufacturing process
Helps to promote healthy mood balance
Helps relieve pain due to
osteoarthritis
Made with hypoallergenic, vegan ingredients
SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also promotes healthy mood balance, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood, believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and
serotonin. It also promotes healthy
protein
turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.
Osteoarthritis
(OA) is the most common type of arthritis
It affects almost all of us as we age. OA usually has a gradual onset and tends to begin after the age of forty. The knees, hips, fingers and spine are the most susceptible joints. This type of arthritis will affect one or only a few joints at a time, and usually won’t symmetrically affect both sides of the body at the same time (although that is possible). This is a degenerative condition that tends to worsen over time, especially with increased use of the affected joints.
How does it happen?
Most commonly, bouts of OA result from an injury to the joint, which causes some local damage that the body fails to properly repair. Unlike
rheumatoid arthritis, the joint deterioration in OA is due to faulty or deficient repair of bone and cartilage in the joint. This can be due to lack of the essential nutrients required for repair, or due to faulty sensory and repair mechanisms in the body. For more information on joint function and the structure of the joint
capsule, please see our
Joint Health
article.
Signs and Symptoms
The largest indicator of Osteoarthritis is a motion induced pain in the joints and stiffness that is worse after a period of inactivity such as when resting or upon waking. At first, there will likely not be any inflammation in the joint however as the condition continues the joint will become damaged and begin to swell and change shape. Surrounding muscles may spasm and many people report a grinding feeling in the joint upon moving. Eventually, the affected joint will emanate constant pain even when it is immobile. Most occurrences of osteoarthritis are not symmetrical and only affected one side, for example, the left hand and not the right. One small joint in a finger can be effected without causing pain in the other joints. When the arthritis is more widespread and symmetrical, it is more likely an inflammatory condition called:
Rheumatoid Arthritis (RA).
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Product Details
PURE ENCAPSULATIONS
SAMe (S-Adenosylmethionine)
Enhanced-stability SAMe to support healthy mood balance and osteoarthritic joint comfort
Provides 200 mg per capsule of enhanced-stability form SAMe
Manufactured using a solvent-free manufacturing process
Helps to promote healthy mood balance
Helps relieve pain due to
osteoarthritis
Made with hypoallergenic, vegan ingredients
SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also promotes healthy mood balance, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood, believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and
serotonin. It also promotes healthy
protein
turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.
Osteoarthritis
(OA) is the most common type of arthritis
It affects almost all of us as we age. OA usually has a gradual onset and tends to begin after the age of forty. The knees, hips, fingers and spine are the most susceptible joints. This type of arthritis will affect one or only a few joints at a time, and usually won’t symmetrically affect both sides of the body at the same time (although that is possible). This is a degenerative condition that tends to worsen over time, especially with increased use of the affected joints.
How does it happen?
Most commonly, bouts of OA result from an injury to the joint, which causes some local damage that the body fails to properly repair. Unlike
rheumatoid arthritis, the joint deterioration in OA is due to faulty or deficient repair of bone and cartilage in the joint. This can be due to lack of the essential nutrients required for repair, or due to faulty sensory and repair mechanisms in the body. For more information on joint function and the structure of the joint
capsule, please see our
Joint Health
article.
Signs and Symptoms
The largest indicator of Osteoarthritis is a motion induced pain in the joints and stiffness that is worse after a period of inactivity such as when resting or upon waking. At first, there will likely not be any inflammation in the joint however as the condition continues the joint will become damaged and begin to swell and change shape. Surrounding muscles may spasm and many people report a grinding feeling in the joint upon moving. Eventually, the affected joint will emanate constant pain even when it is immobile. Most occurrences of osteoarthritis are not symmetrical and only affected one side, for example, the left hand and not the right. One small joint in a finger can be effected without causing pain in the other joints. When the arthritis is more widespread and symmetrical, it is more likely an inflammatory condition called:
Rheumatoid Arthritis (RA).
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